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Date: November 16, 2025 Source: Cochrane Summary: GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility

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Stopping is reasonable only if you've achieved your weight goal, sustained behavioral changes for months, and have a clear plan to prevent regain through diet and exercise

These compounds activate the receptors of a putative endogenous ligand in the hypothalamus and pituitary

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